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This paper details mechanisms by which RNA viruses beyond just SARS-CoV-2 have be connected to long-term health consequences. It is likely that individual patients with a PASC diagnosis have different underlying biological factors driving their symptoms, none of which are mutually exclusive. These patients are being given the diagnosis Long COVID or Post-acute sequelae of COVID-19 (PASC). Across the globe, a subset of patients who sustain an acute SARS-CoV-2 infection are developing a wide range of persistent symptoms that do not resolve over the course of many months. The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of coronavirus disease 2019 (COVID-19). 2Division of Neurotherapeutics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.1PolyBio Research Foundation, Kenmore, WA, United States.Certain Human Genome Variants and/or Herv Activity May Facilitate Pasc DevelopmentĪmy D.SARS-CoV-2 and/or Related Inflammatory Insults May Disrupt Brainstem Signaling.SARS-CoV-2 May Promote Extended “Autoantibody” Production, Often via Molecular Mimicry.Microbiome Dysbiosis Can Disrupt Host Metabolic and Neuroendocrine Signaling and/or Epithelial Barrier Function.SARS-CoV-2 May Dysregulate Host Microbiome/Virome Balance by Facilitating Pathobiont Virulence.SARS-CoV-2 or Reactivated Pathogens May Induce Pathological Immune Cell Signaling or Prime Glia.
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SARS-CoV-2 May Impact the Activity of Bacteria, Fungi, and Parasites.Immune Dysregulation Promoted by SARS-CoV-2 Can Lead to Reactivation of Already Acquired Neurotrophic Pathogens Such as Herpesviruses.SARS-CoV-2 Appears Capable of Persistence in Certain Tissues.SARS-CoV-2 Can Cause Injury to One or Multiple Organs or Tissues.The Neuroinvasive and Neurotrophic Potential of SARS-CoV-2.The editor and reviewer's affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Oxygen Xml Editor 20.Texas Christian University, United States
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